Most compounded ED products on this page build around PDE5 inhibitors — the same drug class as Viagra and Cialis. Rodeo and MadeMed both go a step further, adding an ingredient specifically aimed at desire rather than blood flow alone. They just chose different ones: Rodeo uses apomorphine, MadeMed uses PT-141 (bremelanotide).

RodeoMadeMed
FormatSublingual chewDissolving troche (lozenge)
IngredientsApomorphine, vardenafil, sildenafil, tadalafil (4 total)Tadalafil, PT-141, oxytocin (3 total)
"Desire" ingredientApomorphinePT-141 (bremelanotide)
Price$69/month subscription$119/month, or $89/refill quarterly
PDE5 inhibitors includedThree (vardenafil, sildenafil, tadalafil)One (tadalafil)
Compounded medication notice: both products are compounded and not themselves FDA-approved, though every individual active ingredient in each has independent FDA-approved uses elsewhere. Speak with the prescribing clinician about which combination fits your situation.

Apomorphine vs. PT-141

These work through different mechanisms. Apomorphine acts on dopamine pathways in the brain. PT-141 (bremelanotide) works through melanocortin receptors — it's the same compound studied and FDA-approved on its own (as Vyleesi) for low sexual desire in women, used off-label here as part of a men's ED formula. Neither is a PDE5 inhibitor; both are included specifically to address desire rather than blood flow.

Ingredient Count and Price

Rodeo packs three PDE5 inhibitors plus apomorphine into one dose — four ingredients total. MadeMed uses one PDE5 inhibitor (tadalafil) plus PT-141 and oxytocin — three ingredients. Rodeo's $69/month undercuts MadeMed's $119/month monthly price, though MadeMed's quarterly refill option brings the effective monthly cost down to $89.

Bottom Line

If you want more PDE5-inhibitor coverage in one dose, Rodeo has three to MadeMed's one. If PT-141 specifically is the ingredient you're interested in for desire, that's MadeMed's lane, not Rodeo's. Price favors Rodeo outright at the monthly rate; MadeMed narrows that gap on the quarterly plan.

4-in-1 Sublingual Chew

Rodeo

A sublingual chew combining apomorphine, vardenafil, sildenafil, and tadalafil. $69/month subscription, cancel anytime.

Compounded medication notice: not FDA-approved. Speak with the prescribing clinician about your options.

View Rodeo
Compounded 3-in-1 Troche

MadeMed

A dissolving troche combining tadalafil, PT-141, and oxytocin. $119/month, or $89/refill quarterly.

View MadeMed
What's the difference between apomorphine and PT-141?
Both target sexual desire rather than blood flow directly, but through different mechanisms — apomorphine acts on dopamine pathways, while PT-141 (bremelanotide) works through melanocortin receptors. PT-141 is the same compound FDA-approved on its own for low desire in women, used off-label here as part of a men's formula.
Is Rodeo or MadeMed cheaper?
Rodeo's $69/month is cheaper than MadeMed's $119/month standard rate. MadeMed's quarterly refill plan brings its effective cost to $89/refill, narrowing but not closing the gap.
Related on EdClinic
Advertising disclosure: EdClinic.co is an independent comparison site. We may earn a commission when you visit a provider through a link on this page — this does not affect the price you pay. Compounded medications referenced on this page are not FDA-approved; compounding pharmacies prepare medications under a licensed clinician's prescription. Nothing on this page is medical advice. Talk to a licensed healthcare provider about your specific situation.